Allergic Skin Disorders

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Abstract
ALLERGIC skin diseases are relatively common and, at times, devastating clinical problems that have great socioeconomic impact. In this section, we will provide a basis for understanding the role of immune mechanisms in the cause of certain diseases of the skin and the application of this information to their diagnosis and treatment. ATOPIC DERMATITIS Definition Atopic dermatitis1,2is a common dermatitis that is characterized by severe pruritus, frequent onset in infancy, a strong familial propensity, and a tendency toward chronicity. It is referred to asatopic dermatitisbecause of its occurrence in individuals who manifest IgE-mediated skin test reactions and who later frequently acquire allergic rhinitis, asthma, or both. Typically, atopic dermatitis begins in early infancy, rarely before age 2 months but before age 6 months in the majority of instances. The expression of the disease in early life, when it occurs as an erythematous, papulovesicular, exudative, intensely pruritic

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