Heme Stimulation of Globin Synthesis in a Cell Free System
- 20 May 1966
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3725) , 1080-1082
- https://doi.org/10.1126/science.152.3725.1080
Abstract
In a cell-free system of pigeon erythrocyte nuclei high concentrations of oxygen inhibit globin synthesis because of the inhibition of heme synthesis, which is required for globin synthesis. The effect of heme in overcoming the inhibition of globin synthesis by oxygen is manifested only during the first few minutes of incubation. This period represents the time during which the system is being warmed from 4° to 37°C. The effect of heme seems to be upon some initial assembly or structural process.Keywords
This publication has 3 references indexed in Scilit:
- Control of hemoglobin synthesis by oxygen tension in a cell-free systemArchives of Biochemistry and Biophysics, 1965
- The effects of oxygen concentration on porphyrin biosynthesis in chicken-erythrocyte preparationsBiochemical Journal, 1964
- Protein synthesis in nuclei of avian erythrocytesBiochemical and Biophysical Research Communications, 1962