Relationship between plasma propranolol concentration and dose in young, healthy volunteers
- 1 March 1986
- journal article
- research article
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 7 (2) , 103-111
- https://doi.org/10.1002/bdd.2510070202
Abstract
The relationship between dose and bioavailability of propranolol was determined in 12 healthy male subjects. The doses employed were 10, 40, 80 or 160 mg of propanolol HCI given three times daily for 4 days. Daily minimum plasma levels showed that there was no accumulation of the drug. In all subjects, non‐linear relationships were observed between peak plasma level, or area under the plasma concentration‐time curve, and dose. The between subject variation of these parameters was not dose related.Keywords
This publication has 7 references indexed in Scilit:
- Variable first-pass elimination of propranolol following single and multiple oral doses in hypertensive patientsEuropean Journal of Drug Metabolism and Pharmacokinetics, 1982
- Kinetics and cardiac effects of propranolol in humansJournal of Molecular Medicine, 1982
- Clinical Pharmacokinetics of PropranololClinical Pharmacokinetics, 1979
- The predictable relationship between plasma levels and dose during chronic propranolol therapyClinical Pharmacology & Therapeutics, 1978
- Disposition of propranolol V. Drug accumulation and steady‐state concentrations during chronic oral administration in manClinical Pharmacology & Therapeutics, 1973
- The Disposition of PropranololPharmacology, 1972
- The pharmacodynamics and metabolism of propranolol in manEuropean Journal of Clinical Pharmacology, 1970