Experimental Induction of Hemorrhagic-Aplastic Anemia in Chickens II. Serum Protein Changes

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Abstract
The serologic response of chickens to infectious bursal disease virus (IBDV) and inclusion body hepatitis virus (IBHV) was analyzed. Inoculation at 1 day old with IBDV or IBHV significantly (P < 0.05) reduced levels of serum gamma-globulins at 4 wk postinoculation. This response was not elicited by inoculation of IBDV together with IBHV. Birds with experimentally induced or naturally occurring hemorrhagic anemia syndrome (HAS) had serum proteins quantitatively and qualitatively changed from those of controls. Serum protein profiles did not coincide in experimentally infected and naturally infected chickens. Among naturally infected chickens, those that were IBHV-positive on culture had significantly (P < 0.05) lower hematocrit values.