Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones.
Open Access
- 1 January 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 49 (1) , 173-176
- https://doi.org/10.1093/jac/49.1.173
Abstract
Twenty-nine fluoroquinolone (FQ)-resistant clinical isolates of Streptococcus pneumoniae from a collection of isolates from the Alexander Project (1992–1997) and a study from Northern Ireland were identified on the basis of ofloxacin MICs ≥4 mg/L. DNA fingerprint analyses using BOX-fingerprinting and pulsed-field gel electrophoresis revealed serotype 9V and 23F high-level FQ-resistant strains indistinguishable from the pandemic Spain23F-1 and Spain9V-3 clones, the type strains of which are low-level resistant or susceptible to the fluoroquinolones.Keywords
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