Liver Function Following Partial Devascularization of the Liver

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Abstract
Interference with the blood supply of the liver of the dog caused only minor changes in serum cholesterol, cholesterol esters, and fasting blood sugar. It frequently caused an increase in alkaline phosphatase which seemed not to be in proportion to the degree of devascularization. The total plasma protein was not lowered significantly but the albumin fraction decreased markedly and the A/G ratio was reversed usually in proportion to the degree of interference to the hepatic circulation and more pronounced the longer the time interval between extensive devascularization and the tests. Interference with the blood supply of the liver apparently has its most pronounced effect on the protein metabolism of the liver. Similar findings might be expected in patients with impaired hepatic circulation.