ARE TUMOR-ASSOCIATED TRANSPLANTATION ANTIGENS OF CHEMICALLY INDUCED SARCOMAS RELATED TO ALIEN HISTOCOMPATIBILITY ANTIGENS?

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Abstract
The hypothesis tested was that tumor-specific transplantation antigens of chemically induced tumors cross-react with allogeneic histocompatibility antigens. This hypothesis makes several predictions that can be tested experimentally. First, tumors should grow better and be less immunogenic in certain F1 hybrids than in their syngeneic parents, owing to the hypothecated cross-reactivity of the tumor-specific transplantation antigens with F1 antigens. This is in contrast to the more common observation that parental strain tumors grow worse in the F1 hybrids than they do in the parent. Also certain allogeneic skin grafts might immunize the parental strain mice against their syngeneic tumors, and, finally, immunizing parental mice with syngeneic tumor might cause accelerated rejection of certain skin allografts. The results show that certain tumors grew better in the F1 mice than they did in the parents but that the tumors were not less immunogenic in the F1 hybrids. Mice immunized against alloantigens showed a dose-dependent enhancement of syngeneic tumor growth. Finally, mice immunized with syngeneic tumors demonstrated an apparent prolongation of certain skin allografts. The discussion considers possible alternatives explaining these results.
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