Radiation-Induced Alteration of Fibrinogen Clotting Rate and Clot Lability.

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Abstract
Purified bovine fibrinogen was exposed to single X-ray doses in the ranges of 25-100 r and 100-500 r. In each case the logarithm of the thrombin clotting time increased linearly with increasing dosage. Clotting delay due to irradiation was dependent on the thrombin concentration but independent of fibrinogen concentration. Addition, of sulfhydryl reagents prior to irradiation, did not abolish the radiation-induced clotting defect. Irradiation of fibrinogen increased the rate of solution in concentrated urea of the fibrin clots obtained after addition of thrombin.

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