IODIDE ORGANIFICATION DEFECT IN A COLD THYROID NODULE: ABSENCE OF IODIDE EFFECT ON CYCLIC AMP ACCUMULATION
- 1 April 1984
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 20 (4) , 473-479
- https://doi.org/10.1111/j.1365-2265.1984.tb03444.x
Abstract
A follicular adenoma of the thyroid was hot 1 h after 99mTc pertechnetate administration, but cold 24 h after 131I iodide administration. Incubation of the tissue in vitro demonstrated a defect in iodide binding to proteins that was abolished by addition of an H2O2 generating system. In this tissue iodide failed to inhibit TSH-induced cAMP accumulation. Iodide oxidation is required for its inhibitory action on cAMP accumulation in human thyroid.Keywords
This publication has 24 references indexed in Scilit:
- EFFECTS OF HUMAN THYROID-STIMULATING HORMONE AND IMMUNOGLOBULINS ON ADENYLATE CYCLASE ACTIVITY AND THE ACCUMULATION OF CYCLIC AMP IN HUMAN THYROID MEMBRANES AND SLICESJournal of Endocrinology, 1978
- Discrepancies between iodine and technetium thyroid scintigraphyPublished by American Medical Association (AMA) ,1978
- Biosynthesis of thyroid hormone: Basic and clinical aspectsMetabolism, 1977
- Benign Thyroid Nodule with Normal Iodide Trap and Defective OrganificationJournal of Clinical Endocrinology & Metabolism, 1975
- A SIMPLIFIED METHOD FOR MEASURING THYROIDAL UPTAKE OF TECHNETIUM99m USING DIRECTIONAL COUNTINGJournal of Endocrinology, 1973
- Demonstration of Iodide Transport Defect but Normal Iodide Organification in Nonfunctioning Nodules of Human Thyroid GlandsJournal of Clinical Investigation, 1973
- Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of “cold” thyroid nodules and normal human thyroid tissueJournal of Clinical Investigation, 1972
- Evidence for a clonal origin of head and neck tumorsInternational Journal of Cancer, 1972
- REGULATION OF THE RELEASE OF THYROID HORMONES: ROLE OF CYCLIC AMP*Annals of the New York Academy of Sciences, 1971
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970