PHARMACODYNAMICS OF MIVACURIUM IN CHILDREN, USING A COMPUTER-CONTROLLED INFUSION
Open Access
- 1 August 1993
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 71 (2) , 232-237
- https://doi.org/10.1093/bja/71.2.232
Abstract
A computerized infusion system was used to determine requirement for a mivacurium infusion to maintain a 95% and a 50% neuromuscular block in 21 children aged 1–15 yr. Neuromuscular block was measured by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50–100 μg kg−1 h−1. The targeted neuromuscular block was reached within mean 5 (SD 3) min from initiation of an infusion. Mivacurium requirement for 95% neuromuscular block was 950 (350) μg kg−1 h−1, which represented an hourly requirement of 6.8 (1.6) individual ED95 doses. Infusion requirement for 50% neuromuscular block averaged 350 (150) μg kg−1 h−1. There was a significant negative correlation between infusion rate and age of a patient. Great individual variation of the infusion rate makes a computerized infusion an easy method to achieve and maintain a desired level of neuromuscular block. No side effects of mivacurium were noticed.Keywords
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