A Histologic Study of Endoscopic Biopsies of the Gastric Remnant Mucosa Following Subtotal Gastrectomy, with Special Reference to Changes of the Stomal Mucosa

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Abstract
Endoscopic biopsy specimens of the remnant gastric mucosa (and of the stomal mucosa in particular) were investigated in 219 patients who had received subtotal gastrectomy for gastric cancer. Dilated glandular lumina (glandular dilatation) and curved ducts (irregular glandular structure) were detected significantly more freguently in the group gastrectomized long before, or by Billroth II resection, than in those treated recently, or by Billroth I resection. DNA histograms showed a distribution of epithelial cells from the remnant gastric mucosa which was somewhat different from the normal histogram. The occurrence rates of polyploid cells were significantly higher than normal, and tended to increase in the same individuals with advancing time after gastrectomy. These observations suggested that the pavticulav environments of the gastric remnant might have nonphvsiologic influences upon the gastric mucosa, although further studies are essential for the clarification of the possible relationship of these environments to oncogenesis in the remnant stomach.

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