Fluorescence of Melanoma Cells: A Useful Diagnostic Tool

Abstract
Fluorescence seen in unstained sections from formalin-fixed, paraffin-embedded tissue from cases of malignant melanoma was studied. Fourteen of 16 primary cutaneous melanomas and six of eight metastatic melanomas were positive for yellowgreen fluorescence. Four of 15 nevocellular nevi were also positive. Various other cutaneous tumors examined were completely negative. This fluorescence, which can be easily demonstrated, may be used as a valuable ancillary diagnostic test for differentiating melanoma cells from other cutaneous tumor cells.

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