A comparison of the respiratory depressant effects of dextropropoxyphene and codeine in man

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Abstract
Twelve volunteers were given placebo and graded doses of codeine and dextropropoxyphene to determine the relative respiratory potency of oral dextropropoxyphene and oral codeine. Carbon dioxide response curves were prepared from data accumulated with a rebreathing technique. The relative respiratory potency, p, was calculated as 0.33. According to this calculation, 180 mg. of dextropropoxyphene administered orally produces respiratory depression equal to that of 60 mg. of codeine orally.

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