Association of a Single‐Nucleotide Polymorphism in the Pregnane X Receptor (PXR63396C→T) with Reduced Concentrations of Unboosted Atazanavir
Open Access
- 1 November 2008
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 47 (9) , 1222-1225
- https://doi.org/10.1086/592304
Abstract
This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T→C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P=.008) and 5.13 (P=.02). Prospective studies determining potential clinical usefulness are now warranted.Keywords
This publication has 18 references indexed in Scilit:
- Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patientsJournal of Antimicrobial Chemotherapy, 2008
- Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cellsBritish Journal of Pharmacology, 2008
- Novel Single Nucleotide Polymorphisms in the Promoter and Intron 1 of Human Pregnane X Receptor/NR1I2 and Their Association with CYP3A4 ExpressionDrug Metabolism and Disposition, 2008
- The private sector and HIV/AIDS in Africa: taking stock of 6 years of applied researchAIDS, 2007
- Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemiaAIDS, 2007
- Population Pharmacokinetics of Atazanavir in Patients with Human Immunodeficiency Virus InfectionAntimicrobial Agents and Chemotherapy, 2006
- Pharmacogenetics of HIV therapyPharmacogenetics and Genomics, 2006
- Plasma Levels of Atazanavir and the Risk of Hyperbilirubinemia Are Predicted by the 3435C->T Polymorphism at the Multidrug Resistance Gene 1Clinical Infectious Diseases, 2006
- Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by RifampinJournal of Biological Chemistry, 2001
- Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavirBritish Journal of Clinical Pharmacology, 1997