Total Synthesis of PDE-I
- 1 March 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 43 (3) , 559-561
- https://doi.org/10.1080/00021369.1979.10863473
Abstract
PDE-I (I), a new inhibitor of cyclic adenosine-3′,5′-monophosphate phosphodiesterase, was synthesized in seven steps of reactions from 1-acetyl-2,3-dihydro-7-hydroxy-6-methoxy-5-nitro indole (III) via the key intermediate, 5-amino-1-carbamoyl-2,3-dihydro-7-hydroxy-6-methoxy indole (VII), which has the hydroindole skelton and the sites for the introduction of the pyrrole moiety necessary for the preparation of I.This publication has 0 references indexed in Scilit: