Studies on the Medicinal Resources. XVIII
- 1 January 1961
- journal article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 81 (4) , 558-559
- https://doi.org/10.1248/yakushi1947.81.4_558
Abstract
Extraction of fresh leaves of Lonicera japonica THUNB. with methanol and treatment of the methanolic extract with lead acetate afforded pale yellow microneedles, m.p. 218°, [α]D19 -83.5°, C27H30O15⋅2H2O, in 0.01% yield. This substance was named lonicerin. Hydrolysis of lonicerin with 5% sulfuric acid gave luteolin, rhamnose, and glucose. Permethylation of lonicerin followed by hydrolysis afforded 3′, 4′, 5-tri-O-methylluteolin. It follows, therefore, that the sugar is bonded at the 7-position and that lonicerin is luteolin 7-rhamnoglucoside.Keywords
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