Chromosome anomalies as predictors of recurrence risk for spontaneous abortion
- 1 October 1987
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 28 (2) , 353-360
- https://doi.org/10.1002/ajmg.1320280213
Abstract
Reproductive histories and chromosomes of spontaneous abortions were studied by segregation analysis in 1890 sibships ascertained through a cytogenetically studied abortion. Normal karyotypes are associated with recurrent abortion. Among abnormal karyotypes, trisomy has an elevated recurrence risk even after adjustment through a liability indicator for maternal age. Possible mechanisms and conflicting evidence in the literature on trisomy are discussed. None of these differences in recurrence risk is large enough to play a significant numerical role in genetic counseling.Keywords
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