A Highly Efficient, Selective, and General Method for the Synthesis of Conjugated (all-E)-Oligoenes of the (CHCH)n Type via Iterative Hydrozirconation−Palladium-Catalyzed Cross-Coupling
- 8 February 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (5) , 703-706
- https://doi.org/10.1021/ol0102794
Abstract
A linear iterative method for the construction of (all-E)-oligoenes of the (CHCH)n type via hydrozirconation−palladium-catalyzed cross-coupling with (E)-1-bromo-4-trimethylsilyl-1-buten-3-yne is described. This method promises to provide an efficient, selective, and general route to oligoene macrolide antibiotics and other related natural products.Keywords
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