THE RAPID LOWERING OF HAEMATOCRIT BY EXCHANGE TRANSFUSION OF RHEOMACRODEX® DEXTRAN 40

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Abstract
Exchange transfusion using dextran 40 has been described in 31 patients. This would appear to be a safe and logical procedure for treating both primary and secondary polycythaemia where venesection would normally be considered. As much as 3.5 1 of blood may be removed rapidly at a time without harming the patient. The method may also be of benefit in thrombotic disease as it allows a much larger loading dose of dextran 40 than could normally be given safely. It is suggested that the resultant fall in haematocrit may be important in improving tissue perfusion despite loss of oxygen carrying capacity. A clinical trial of the procedure in the various conditions mentioned is planned in the Island of Guernsey in conjunction with studies at Guy's Hospital, London.