Anti-Inflammatory and Anti-Nociceptive Activity of Disodium Glycyrrhetinic Acid Hemiphthalate
- 1 August 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 62 (04) , 326-328
- https://doi.org/10.1055/s-2006-957894
Abstract
The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3β-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the rat paw edema induced by carrageenin (ID50 = 21.37 mg/kg), and mice writhing responses caused by acetic acid (ID50 = 9.12 mg/kg). The potency of disodium glycyrrhetinic acid hemiphthalate was about 13.05 times higher than acetylsalicylic acid in inhibiting rat paw edema and 12.84 times higher in inhibiting abdominal constrictions in mice.Keywords
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