CONNECTIVE-TISSUE FORMATION BY LUNG FIBROBLASTS INVITRO

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Abstract
Guinea pig lung fibroblasts were grown in monolayer culture after enzymatic disaggregation of lung parenchyma. Light microscopy and EM indicated that the cultures were relatively homogeneous with respect to cell type. Matrix glycosaminoglycan and collagen synthesis was demonstrated throughout the culture life. The guinea pig cell strains are suitable in vitro models for studying the regulation of connective tissue metabolism of pulmonary tissue [with applications in lung disease pathogenesis].