Prolonged Inhibition of Vascular Contraction and Calcium Influx by the Novel 1,4-Dihydropyridine Calcium Antagonist Cinaldipine (FRC-8653).
- 1 January 1991
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 56 (2) , 225-229
- https://doi.org/10.1254/jjp.56.225
Abstract
We examined the effects of FRC-8653, a novel dihydropyridine calcium antagonist, on the contraction of an arterial preparation and the calcium influx into vascular smooth muscle cells to clarify the long-lasting hypotensive activity of this drug. Inhibition by FRC-8653 persisted for more than 7 hr after its removal, whereas nifedipine and nicardipine exhibited shorter durations of suppressive activity. These results suggest that prolonged inhibition of calcium influx through L-channels contributes to the long-lasting vasodilative and antihypertensive activity of FRC-8653.Keywords
This publication has 0 references indexed in Scilit: