ORGANIC ANION-BINDING PROTEIN IN RAT LIVER: DRUG INDUCTION AND ITS PHYSIOLOGIC CONSEQUENCE
- 1 September 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (1) , 168-170
- https://doi.org/10.1073/pnas.64.1.168
Abstract
The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.Keywords
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