Chromosome mapping of cell membrane antigens expressed on activated B cells

Publisher Website
Google Scholar
Abstract
Hybrids formed by fusion of either human acute lymphoblastic or chronic lymphocy-tic leukemia cells and the mouse myeloma P3.X63.Ag81653 have been used to show that the expression of two cell surface antigens, Bp37 and p76, associated with B cell activation and detected by the monoclonal antibodies BB1 and BB2, respectively, segregate with human chromosomes 12 and 19, respectively. Another antigen expressed on activated B cells (p24) also maps to chromosome 12 (Katz et al., Eur. J. Immunol. 1984.13:1008) which is of interest in the light of the frequent involvement of this chromosome in certain B cell leukemias and lymphomas.