Frequent Detection of Viral Nucleic Acids in Heart Valve Tissue
Open Access
- 1 May 2004
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 42 (5) , 2298-2300
- https://doi.org/10.1128/jcm.42.5.2298-2300.2004
Abstract
Due to a paucity of published data concerning the prevalence of viral nucleic acid in homografts, we analyzed tissue from 30 donor hearts for the presence of viral genome sequences of enteroviruses, adenoviruses, human cytomegalovirus, and influenza virus using different PCR techniques. Viral DNA was amplified in 64 and 52% of the subvalvular myocardial tissue and non-coronary valve samples, respectively. These findings, compared with clinical history and histologic and serologic analysis, demonstrate the importance of viral safety measures in heart valve banking.Keywords
This publication has 12 references indexed in Scilit:
- An outbreak of viral meningitis associated with a public swimming pondEpidemiology and Infection, 2004
- Analysing myocardial tissue from explanted hearts of heart transplant recipients and multi-organ donors for the presence of parvovirus B19 DNAJournal of Clinical Virology, 2004
- Viral causes of cardiac inflammationCurrent Opinion in Cardiology, 2003
- Nachweis viraler Genomstrukturen im Myokardgewebe von HerzklappenspendernZeitschrift für Herz-,Thorax- und Gefäßchirurgie, 2003
- Infections and their role in atherosclerotic vascular diseaseThe Journal of the American Dental Association, 2002
- Association of Viral Genome with Graft Loss in Children after Cardiac TransplantationNew England Journal of Medicine, 2001
- Application of a Fluorogenic PCR Assay for Typing and Subtyping of Influenza Viruses in Respiratory SamplesJournal of Clinical Microbiology, 2000
- Detection of adenovirus using PCR and molecular beaconJournal of Virological Methods, 1999
- [Homograft in the therapy of cardiovascular diseases].1997
- Polymerase chain reaction assay for detection of human cytomegalovirusJournal of Clinical Microbiology, 1989