Disaccharidases in Celiac Disease and Mucoviscidosis

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Abstract
Activities of disaccharidases were studied in 115 jejunal biopsies af adults and children with celiac sprue (both florid and in remission), of patients with mucoviscidosis (with normal histological findings in the jejunal mucosa) and of control persons. Results of both biochemical and histochemical methods were compared with the histological picture. Patients with florid celiac sprue have a lowered activity of all disaccharidases (particularly of lactase and trehalase). In the remission of celiac sprue these activities improved. The improvement of lactase and trehalase proceeds more slowly than that of other disaccharidases. Patients with mucoviscidosis have significantly lower activities of trehalase than control persons. It is not possible to pass a correct judgement on the level of disaccharidase activities on the basis of the histological picture alone. Histochemical methods are sufficient for the assessment of disaccharidase activities in routine practice. For a correct quantitative determination biochemical methods are indispensable, however. The necessity of the determination of disaccharidase activities in whole non-centrifuged homogenates of biopsies was pointed out.

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