FIRST-TRIMESTER BIOCHEMICAL SCREENING FOR DOWN SYNDROME WITH THE USE OF PAPP-A, AFP, AND β-hCG
- 1 May 1996
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 16 (5) , 405-410
- https://doi.org/10.1002/(sici)1097-0223(199605)16:5<405::aid-pd868>3.0.co;2-y
Abstract
Biochemical screening for Down syndrome (DS) is well established in the second trimester of pregnancy, but there is little information available on its value in the first trimester. This study describes our preliminary results with biochemical screening for DS in the first trimester of pregnancy in order to evaluate its efficacy at this time. Our study population, including 19 DS pregnancies, was evaluated using maternal serum levels of alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (beta-hCG), and pregnancy-associated plasma protein A (PAPP-A). At a false positive rate (FPR) of 5 per cent, the detection rate (DR) for DS is 9 per cent for beta-hCG, 18 per cent for AFP, and 66 per cent for PAPP-A when considering these parameters individually. With different combinations of the analytes, the best detection rates are obtained with the association of PAPP-A and AFP (85 and 82 per cent DR for a 10 and 5 per cent FPR, respectively). Our data support the value of first-trimester biochemical screening for DS and that of PAPP-A as a single marker.Keywords
This publication has 32 references indexed in Scilit:
- Analysis of maternal serum alpha‐fetoprotein and free beta human chorionic gonadotrophin in the first trimester: Implications for down's syndrome screeningPrenatal Diagnosis, 1995
- First trimester maternal serum pregnancy‐associated plasma protein A and pregnancy‐specific βl‐glycoprotein in fetal trisomiesBJOG: An International Journal of Obstetrics and Gynaecology, 1994
- Serum PAPP‐A and free β‐hCG are first‐trimester screening markers for down syndromePrenatal Diagnosis, 1994
- Supported in part by grant No. HD04612 to the Mental Retardation Research Center. Presented at the Fifty-ninth Annual Meeting of the Pacific Coast Obstetrical and Gynecological Society, Ojai, California, October 1118, 1992.American Journal of Obstetrics and Gynecology, 1993
- First‐trimester maternal serum unconjugated oestriol and alpha‐fetoprotein in fetal Down's syndromePrenatal Diagnosis, 1991
- Ultrasound and Biochemical Assessment of First Trimester PregnancyPublished by Springer Nature ,1991
- First‐trimester maternal serum biochemical indicators in Down syndromePrenatal Diagnosis, 1990
- Human chorionic gonadotropin levels in pregnancies with aneuploid fetusesPrenatal Diagnosis, 1989
- Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalitiesPrenatal Diagnosis, 1987
- FETAL CHROMOSOMAL ANEUPLOIDIES AND MATERNAL SERUM ALPHA-FETOPROTEIN LEVELS IN FIRST TRIMESTERThe Lancet, 1986