Synthesis of 11-deoxy-18-hydroxycorticosterone and 18-hydroxycorticosterone 21-acetates
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 22,p. 2252-2256
- https://doi.org/10.1039/p19750002252
Abstract
Functionalisation of the steroid 13-methyl group by nitrite photolysis in the presence of oxygen affords 18-nitrates. The 18-nitrate system provides convenient protection for the 18-hydroxy-group and generates the latter on reduction with zinc under neutral conditions. In this way, convenient syntheses of 11-deoxy-18-hydroxycorticosterone (Xi) and of 18-hydroxycorticosterone (XIIIg) have been completed.Keywords
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