Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil
Open Access
- 1 March 1999
- journal article
- Published by FapUNIFESP (SciELO) in Genetics and Molecular Biology
- Vol. 22 (1) , 1-5
- https://doi.org/10.1590/s1415-47571999000100001
Abstract
A sample of 502 individuals from 94 families from Jacobina, State of Bahia, Brazil, was investigated to determine the causal mechanisms involved in Leishmania chagasi (the causal agent of visceral leishmaniasis in the American hemisphere) infection, as measured by the intradermic reaction to antigens derived from this parasite, using complex segregation analyses. The results showed evidence of a major genetic mechanism acting on infection, with a frequency of a recessive (or additive) susceptibility gene (q) of approximately 0.45. A small multifactorial component (H = 0.29) acting in conjunction with a major recessive gene (q = 0.37) is not ruled out as a concomitant causative factor.Keywords
This publication has 43 references indexed in Scilit:
- Genetic Epidemiology of the Mitsuda Reaction in LeprosyHuman Heredity, 1996
- Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred.Journal of Medical Genetics, 1995
- Mapping Creb-1 to chromosome 1 in the mouseGenomics, 1992
- Genetic regulation of macrophage priming/activation: the Lsh gene storyImmunology Letters, 1991
- Genetic epidemiology of the susceptibility to leprosy.Journal of Clinical Investigation, 1987
- Genetic regulation of resistance to intracellular pathogensNature, 1982
- Influence of H–2 complex on acquired resistance to Leishmania donovani infection in miceNature, 1980
- The genetics of leprosyAnnals of Human Biology, 1979
- Genetics of Resistance to Infection with Salmonella typhimurium in MiceThe Journal of Infectious Diseases, 1976
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974