The gift of Gab
- 6 March 2002
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 515 (1-3) , 1-7
- https://doi.org/10.1016/s0014-5793(02)02425-0
Abstract
Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.Keywords
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