N,N′-bis(Dichloroacetyl)Diamines as Amebicidal Agents
- 1 July 1961
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 10 (4) , 503-509
- https://doi.org/10.4269/ajtmh.1961.10.503
Abstract
Summary The in vitro and in vivo amebicidal activities of eight new synthetic N,N′-bis(dichloroacetyl)diamines are reported. These compounds are amebicidal in vitro against Entamoeba histolytica in concentrations of 1 part in 1 million to as low as 1 part in 50 million. In vivo amebicidal activity was evaluated in hamsters spontaneously infected with Entamoeba criceti. The compounds discussed are highly amebicidal; their calculated ED50 values are in the range of 0.7 to 2.5 mg/kg/day when given for 4 days.This publication has 0 references indexed in Scilit: