Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism

1 January 1992

journal article
research article
Published by Wiley in Movement Disorders

Vol. 7 (1) , 43-47
https://doi.org/10.1002/mds.870070108

Abstract

The antitremor effect of the D₂ agonist LY 171555 and of the D₁ agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D₂ agonist suppressed rest tremor in a dose‐dependent fashion. The D₁ agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.

Keywords

This publication has 16 references indexed in Scilit:

D2 dopamine receptor gene expression by cholinergic neurons in the rat striatum
Neuroscience Letters, 1990
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
Nature, 1990
Monkeys with unilateral ventromedial tegmental lesions of the brain stem: Models for parkinson's disease and lesch-nyhan syndrome
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1989
Evidence for dopamine D-2 receptors on cholinergic interneurons in the rat caudate-putamen
Life Sciences, 1988
Quantitative autoradiography of dopamine D2 sites in rat caudate-putamen: Localization to intrinsic neurons and not to neocortical afferents
Neuroscience, 1987
Stimulation of both D1 and D2 dopamine receptors appears necessary for full expression of postsynaptic effects of dopamine agonists: a neurophysiological study
Brain Research, 1987
Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications
Synapse, 1987
Symptoms and behavioral features induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an old java monkey [Macaca cynamolgus fascicularis (Raffles)]
Brain Research Bulletin, 1986
Dopaminergic mechanisms and motor function: Characterization of D-1 and D-2 dopamine receptor interactions
European Journal of Pharmacology, 1986
The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?
Neuroscience, 1983