Bacterial outer membrane vesicles and the host–pathogen interaction
Top Cited Papers
Open Access
- 15 November 2005
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 19 (22) , 2645-2655
- https://doi.org/10.1101/gad.1299905
Abstract
Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.Keywords
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