Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides.
Open Access
- 1 September 1992
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 176 (3) , 915-918
- https://doi.org/10.1084/jem.176.3.915
Abstract
A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.Keywords
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