Melatonin treatment for circadian rhythm sleep disorders
- 1 April 1998
- journal article
- Published by Wiley in Psychiatry and Clinical Neurosciences
- Vol. 52 (2) , 259-260
- https://doi.org/10.1111/j.1440-1819.1998.tb01063.x
Abstract
We administered 1-3 mg melatonin to 11 patients (eight men, three women, aged 16-46 years) with circadian rhythm sleep disorders; nine with delayed sleep phase syndrome and two with non-24-hour sleep-wake syndrome. Sleep logs were recorded throughout the study periods and actigraph and rectal temperature were monitored during treatment periods. Melatonin was administered 1-2 h before the desirable bedtime for expected phase-shifting, or 0.5-1 h before habitual bedtime for gradual advance expecting an hypnotic effect of the melatonin. Melatonin treatments were successful in 6/11 patients. Timing and dose of melatonin administration, together with its pharmacological properties for circadian rhythm sleep disorders, should be further studied.Keywords
This publication has 2 references indexed in Scilit:
- Delayed sleep phase syndrome response to melatoninThe Lancet, 1991
- Correction of non–24‐hour sleep/wake cycle by melatonin in a blind retarded boyAnnals of Neurology, 1991