Biological properties of dihydro‐leukotriene B4, an alternative leukotriene B4 metabolite
- 25 April 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 231 (2) , 385-388
- https://doi.org/10.1016/0014-5793(88)80855-x
Abstract
Dihydro‐leukotriene B4 (a 5,12‐dihydroxy‐eicosatrienoic acid) has been shown to be the primary metabolite of leukotriene B4, (LTB4) in a variety of cells other than human polymorphonuclear leukocytes (PMNLs). In this report we show that dihydro‐LTB4 is significantly less active than LTB4 in different biological assay systems, i.e. leukocyte chemotaxis, chemokinesis, aggregation, adhesion to endothelium and superoxide anion production. This suggests that primary reduction constitutes a second so far unknown deactivation pathway for LTB4.Keywords
This publication has 16 references indexed in Scilit:
- A novel metabolic pathway for leukotriene B4 in different cell types: primary reduction of a double bondBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
- Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological EffectsScience, 1987
- Conversion of leukotriene B4 to dihydro and 19-hydroxy metabolites by rat polymorphonuclear leukocytesBiochemical and Biophysical Research Communications, 1987
- Role of cytosolic free calcium and phospholipase C in leukotrien‐B4‐stimulated secretion in human neutrophilsEuropean Journal of Biochemistry, 1987
- Leukotriene B4 stimulation of phagocytes results in the formation of inositol 1,4,5-trisphosphate A second messenger for Ca2+ mobilizationBiochemical Journal, 1986
- Effects of leukotrienes and f-Met-Leu-Phe on oxidative metabolism of neutrophils and eosinophils.The Journal of Immunology, 1984
- A rapid method for purification of human granulocytes using percoll®. A comparison with dextran sedimentationJournal of Immunological Methods, 1981
- Aggregation of Leukocytes Induced by the Complement-Derived Peptides C3a and C5a and by Three Synthetic Formyl-Methionyl PeptidesInternational Archives of Allergy and Immunology, 1980
- Stimulation of oxygen consumption and superoxide anion production in pulmonary macrophages by N‐formyl methionyl peptidesFEBS Letters, 1979