An acid-cleavable linker stable at neutral pH that releases doxorubicin at lysosomal pH
- 31 December 1993
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 3 (12) , 2843-2846
- https://doi.org/10.1016/s0960-894x(01)80776-9
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Cure of Xenografted Human Carcinomas by BR96-Doxorubicin ImmunoconjugatesScience, 1993
- Adriamycin(hydrazone)-antibody conjugates require internalization and intracellular acid hydrolysis for antitumor activityCancer Immunology, Immunotherapy, 1991
- Fast hydrolysis of an aliphatic amide at neutral pH and ambient temperature. A peptidase modelJournal of the American Chemical Society, 1988
- Selective delivery of cytotoxic compounds to cells by the LDL pathwayJournal of Medicinal Chemistry, 1984
- Lysosomotropic agents. 4. Carbobenzoxyglycylphenylalanyl, a new protease-sensitive masking group for introduction into cellsJournal of Medicinal Chemistry, 1982
- Synthesis and conformational analysis of cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acidThe Journal of Organic Chemistry, 1981
- Cis-aconityl spacer between daunomycin and macromolecular carriers: A model of pH-sensitive linkage releasing drug from a lysosomotropic conjugateBiochemical and Biophysical Research Communications, 1981
- Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.Proceedings of the National Academy of Sciences, 1978
- Rule governing Cell Division in AnabaenaNature, 1972
- ‘Piggy-Back’ PhagocytosisNature, 1962