18F Labeled Nanoparticles for in Vivo PET-CT Imaging
- 12 January 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 20 (2) , 397-401
- https://doi.org/10.1021/bc8004649
Abstract
We report the synthesis and in vivo characterization of an 18F modified trimodal nanoparticle (18F-CLIO). This particle consists of cross-linked dextran held together in core−shell formation by a superparamagnetic iron oxide core and functionalized with the radionuclide 18F in high yield via “click” chemistry. The particle can be detected with positron emission tomography, fluorescence molecular tomography, and magnetic resonance imaging. The presence of 18F dramatically lowers the detection threshold of the nanoparticles, while the facile conjugation chemistry provides a simple platform for rapid and efficient nanoparticle labeling.Keywords
This publication has 24 references indexed in Scilit:
- Drug‐Loaded Superparamagnetic Iron Oxide Nanoparticles for Combined Cancer Imaging and Therapy In VivoAngewandte Chemie International Edition in English, 2008
- Perturbational profiling of nanomaterial biologic activityProceedings of the National Academy of Sciences, 2008
- Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal AdenocarcinomaPLoS Medicine, 2008
- Nanoparticle PET-CT Imaging of Macrophages in Inflammatory AtherosclerosisCirculation, 2008
- Compact Biocompatible Quantum Dots Functionalized for Cellular ImagingJournal of the American Chemical Society, 2008
- A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune ResponsesPLOS ONE, 2007
- Dual Channel Optical Tomographic Imaging of Leukocyte Recruitment and Protease Activity in the Healing Myocardial InfarctCirculation Research, 2007
- In Vivo Imaging of Molecularly Targeted PhageNeoplasia, 2006
- Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] CycloadditionJournal of the American Chemical Society, 2003
- A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal AlkynesAngewandte Chemie International Edition in English, 2002