Interferon transiently modulates intranuclear signalling system in erythroleukemia friend cells
- 1 May 1991
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 15 (5) , 427-435
- https://doi.org/10.1016/0309-1651(91)90130-b
Abstract
The effect of human recombinant DNA interferon alpha type A on nuclear inositol lipids, diacylglycerol (DAG) and DNA metabolism has been investigated in Friend erythroleukemia cells. A transient enhancement of phosphatidylinositol (4,5) - bisphosphate (PIP2) phosphorylation together with an increase of diacylglycerol mass were observed in nuclei isolated from cells treated with interferon alpha for 90 min. At the same time, a marked reduction of DNA polymerase alpha activity was observed, suggesting a possible involvement of nuclear inositol fraction in the response of the cell nucleus to interferon treatment.Keywords
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