A Partially Successful Attempt at Medical Treatment of Urinary-Stress Incontinence in Women

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Abstract
It has been known for a long time that estrogens can improve or cure a certain number of women with urinary-stress incontinence, but their use has always been limited by their stimulating effect on the endometrium, to which undesirable uterine bleedings may frequently follow. This drawback is not presented by quinestradol, which has a selective action on the lower female genital tract, as well as on the trigone of the bladder and the dorsal part of the urethra. Treatment with quinestradol, 2 mg daily by mouth for cycles of 20 days, has given complete relief of the incontinence in about a third of our patients.

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