INTERFERON EFFECT ON COLLAGEN AND FIBRONECTIN DISTRIBUTION IN THE EXTRACELLULAR-MATRIX OF MURINE SARCOMA VIRUS-TRANSFORMED CELLS
- 1 January 1981
- journal article
- research article
- Vol. 41 (9) , 3629-3634
Abstract
The transformation of murine BALB/c embryonic fibroblasts by murine sarcoma virus, Moloney strain, followed by prolonged treatment with murine interferon, resulted in the appearance of a new cell population (MSV-IF+). These MSV-IF+ cells are characterized by the recovery of a normal phenotype, contact inhibition, and lack of colony formation in agar. This phenotypic change of the MSV-IF+ cells is associated to the neosynthesis of a dense fibrous matrix beyond the cell periphery. Ultrastructural studies using peroxidase-labeled antibodies enabled the localization of the extracellular distribution of fibroncetin and collagen in the MSV-IF+ cell line, compared to normal BALB/c and murine sarcoma virus-transformed cells. In parallel, a significant increase of collagen and fibronectin deposit in the intercellular space of interferon-treated murine sarcoma virus-transformed cells was observed.This publication has 23 references indexed in Scilit:
- Codistribution of pericellular matrix proteins in cultured fibroblasts and loss in transformation: Fibronectin and procollagenProceedings of the National Academy of Sciences, 1978
- Affinity of fibronectin to collagens of different genetic types and to fibrinogen.The Journal of Experimental Medicine, 1978
- EFFECTS OF CELL DENSITY AND TRANSFORMATION ON FORMATION OF A FIBRONECTIN EXTRACELLULAR FILAMENTOUS MATRIX ON HUMAN FIBROBLASTS1978
- Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed cells.The Journal of cell biology, 1977
- Control of a Cell Surface Major Glycoprotein by Epidermal Growth FactorScience, 1977
- Binding of soluble form of fibroblast surface protein, fibronectin, to collagenInternational Journal of Cancer, 1977
- Interferon and cell division *1XII. Prolongation by interferon of the intermitotic time of mouse mammary tumor cells in vitro. Microcinematographic analysisExperimental Cell Research, 1977
- Preparation and use in immunohistology of antibodies specific for type I and type III collagen and procollagenJournal of Immunological Methods, 1976
- Induction of human fibroblast proliferation by epidermal growth factor (EGF): enhancement by an EGF-binding arginine esterase and by ascorbate.Proceedings of the National Academy of Sciences, 1976
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966