Regression of Sheep Corpora Lutea after Treatment with Antibovine Luteinizing Hormone2

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Abstract
The inhibitory effect of horse anti-bovine luteinizing hormone (LH) on luteal function in the estrous ewe was studied. In Experiment I ewes were allotted to three groups and the corpora lutea removed on day 9 of the cycle following treatment with either (1) 20 ml daily of antibovine LH from day 2 through day 6; (2) 20 ml daily of normal horse serum from day 2 through day 6; or (3) no treatment. Subcutaneous injections of the anti-LH serum resulted in a significant reduction in weights of the corpora lutea (P<.01), progesterone contents (P<.01) and progesterone concentrations (P<.05) when compared with control groups. In Experiment II treatment groups were the same as in Experiment I except that 10 ml daily of anti-LH serum and normal horse serum were injected from day 2 through day 8 and the corpora lutea were removed on day 9. Significant decreases in weight of the corpora lutea (P<.01) and progesterone contents (P<.05) were obtained. No difference was found in progesterone concentrations in this group. A large, but statistically (P>.05) non-significant, increase in 20α-ol concentration above control levels was also observed. Control ewes in both experiments exhibited behavioral estrus 2 days following removal of the corpora lutea, whereas ewes treated with anti-LH did not show behavioral estrus until 29 (Experiment I) and 28 (Experiment II) days after surgery. These data indicate that LH is not only a major luteotrophic factor in the ewe, but is also necessary for follicular development and estrogen production. Copyright © 1970. American Society of Animal Science . Copyright 1970 by American Society of Animal Science

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