Der Calciumstoffwechsel verschiedener Organe bei jungen und alten Tieren

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Abstract
Male albino rats, 35 animals, 3 to 31 months old, were injected with 20 microcuries Ca45 in 1 ml Ringers'' solution. Two days later the animals were sacrificed and the distribution of Ca45-activity in the different organs was measured. Ca45-activity decreases sharply in the bones (rib, epiphysis and diaphysis of femur) until the 10th month and then remains fairly constant. The Ca45-exchange was in other organs with low Ca content several hundred times larger (calculated per 1 mg) than in the bones. Especially in the aorta the Ca45-exchange increases during life up to 6 times the value in young animals. The Ca content also increases. The behavior of the lung is similar. It seems possible that here, just as in the aorta, the ageing of the elastic fibers is the cause. The increase of the activity and Ca content in the brain during the life span is also striking. The large intestine has a special role which may be explained by its excretory activities. The increase of Ca45-exchange in the aged animals can be observed also on the tendon fibers and in the skin.