CALCULATION OF LDL-CHOLESTEROL FROM TOTAL CHOLESTEROL, TRIGLYCERIDE AND HDL-CHOLESTEROL - A COMPARISON OF METHODS IN THE JERUSALEM-LIPID-RESEARCH-CLINIC PREVALENCE STUDY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 18  (12) , 1242-1252
Abstract
Methods for estimating the cholesterol content [in humans] of the plasma very low density lipoprotein (VLDL-C) and low-density lipoprotein (LDL-C) fractions were examined in an ethnically diverse population sample from the Jerusalem Lipid Research Clinic Prevalence Study. None of these methods required the use of preparative ultracentrifuge. The often-used method for estimating VLDL-C by multiplying the triglyceride (TG) value by 0.20 was compared with 2 other models in which linear regression functions were computed for VLDL-C (determined by ultracentrifugation) as the dependent variable and TG as the independent variable. Subsequently, the intercept and the slope coefficients were used for estimation of VLDL-C and LDL-C. In the 1st regression model, overall age and sex regression coefficients were applied; in the 2nd regression model, the coefficients were calculated within different TG ranges. All 3 models were similar in their predictive accuracy when applied to the total population sample. In subjects with high TG levels, the 2nd regression model was preferable. [The association between LDL-C ULDL-C and coronary heart disease is discussed.].