Evidence of a Sex-Specific Effect of Testosterone and Progesterone upon L-Cystine-Aminopeptidase Activity in the Hypothalamus and Paleopallium of the Rat

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Abstract
The activity of L-cystine-aminopeptidase (CAPA) in the hypothalamus and paleopallium of the immature, intact male rat could be stimulated by administration of ethinyl oestradiol and testosterone, while progesterone was without effect. No such response was observed in the neopallium, liver, or pituitary. The enzyme activity was measured 16–18 h after injection of the hormones by a colorimetric method using L-cystine-di-β-naphthylamide as substrate. A different response was found in female rats. Progesterone elicited a stimulation of enzyme activity in adult, oophorectomized but not in immature, intact animals. Testosterone did not affect the level of enzyme activity in the immature female rat. There was no difference in the response of males and females to ethinyl oestradiol. These findings indicate a sex-associated difference in the reaction of CAPA in the hypothalamus and paleopallium of the rat to the administration of testosterone and progesterone.

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