A Study of the Chemotherapeutic Activity of Isatin β-4′,4′-Dialkylthiosemicarbazones against Ectromelia Infection

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Abstract
[beta]-4[image],4[image]-Dialkylthiosemicarbazones of isatin itself and of many isatin derivatives show high antiviral chemotherapeutic activity against ectromelia in mice when given subcutaneously. From results obtained with the [beta]-4[image],4[image]-dimethyl, -diethyl-, -di-n-propyl-, -di-n-butyl-, -tetramethylene- and -pentamethylene-thiosemicarbazones and the [beta]-4[image]-methyl-4[image]-phenylthiosemicarbazones of a variety of substituted isatins, certain relations between antiviral activity and chemical structure were observed. Of the 40 compounds studied, isatin [beta]-4[image],4[image]-dimethylthiosemicarbazone and its I-methyl derivative are the most active. Lengthening the alkyl chains diminished the activity, and removing one or both of the 4[image]-alkyl groups abolished it. Substitution in the benzene ring slightly reduces activity. Similar results are obtained using Sandom, Hampstead and Moscow strains of ectromelia virus.

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