A circular dichroism study of poly dG, poly dC, and poly dG:dC

Publisher Website
Google Scholar
Abstract
We have measured the ultraviolet circular dichroism spectra of oligo d(pG)5, poly dN AcG, poly dI, poly dC, two samples of poly dG, and four samples containing double‐stranded poly dG:dC. We find that oligo d(pG)5 and poly dG exist in self‐complexed forms as well as in single‐stranded forms. Unlike the self‐complexed form of poly dG, the single‐stranded form of poly dG can hydrogen‐bond with single‐stranded poly dC. We present spectral data for double‐stranded poly dG:dC, which can be used to help characterize poly dG:dC preparations and which provide a basis for resolving discrepancies among other reported poly dG:dC spectra.