Drug Fever Due to Quinidine

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Abstract
HYPERSENSITIVITY to quinidine is not rare, the symptoms usually taking the form of gastrointestinal disturbances or other reactions similar to those produced by its levo-isomer, quinine. Rarer manifestations include thrombocytopenia, skin rashes and fever.Although all drugs probably can act as allergens, some appear to induce hypersensitivity more readily than others, and only a few oral medications are known to produce drug fever. These include the antipyretics, sulfonamides, the thiouracil derivatives and quinine. Fever as a reaction to quinidine is rare. Since Frey1 introduced quinidine for the treatment of auricular fibrillation more than thirty years ago few cases have been . . .

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