Diffuse Rosenthal Fiber Formation in the Adult: A Report of Four Cases

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Abstract
Four cases of unusual formation of Rosenthal fibers widely distributed in the brain stem, spinal cord and paraventricular areas of the brain are described. No clinical neurological syndrome could be attributed to these pathologic changes. The etiology of these changes is not clear but as has been suggested by Herndon et al, they may be related to a congenital or acquired metabolic defect occurring in the astrocytes leading to an abnormal accumulation of glial filaments.