Effectiveness of calcium antagonist drugs in patients with unstable angina and proven coronary artery disease
- 1 December 1988
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 9 (suppl N) , 158-163
- https://doi.org/10.1093/eurheartj/9.suppl_n.158
Abstract
Eighty-five patients admitted to our CCU for unstable angina (UA) with proven coronary artery disease, in whom i.v. therapy with nilroglycerin (N) and heparin (H) did not reduce both painful and painless episodes of myocardial ischaemia, were treated by i.v. administration of verapamil (V) and diltiazem (D) in order to assess the efficacy of calcium antagonists in reducing myocardial ischaemia. All patients were given i.v. N + H throughout the whole study period; none showed significant increase in serum CK MB concentration. V and D were assigned following a double-blind, cross-over, placebo-controlled design after a 48 h period of N + H therapy. Continuous Hotter monitoring (CHM) was performed during the whole study period. V and D significantly reduced the total number of ischaemic episodes day−1 (Keywords
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